Wegovy vs Mounjaro: What’s the Difference?

If you’ve been looking into weight management injections, you’ve probably come across Wegovy and Mounjaro. Both are popular medications designed to support weight loss, but they aren’t identical. Here’s a breakdown of how they compare, so you can better understand which might be right for you.

What They Have in Common

• Weekly injections: Both Wegovy and Mounjaro are given once a week using a pre-filled pen in the upper arm, thigh or stomach.
• Appetite control: They work by helping you feel fuller for longer and reducing cravings by slowing down your digestion, which supports healthier eating habits.
• Medical supervision: Both require a prescription and ongoing monitoring by a prescriber.
• Lifestyle still matters: Neither is a “quick fix” - they work best alongside healthy eating and regular physical activity.

Key Differences

Active Ingredients

• Wegovy contains semaglutide, a GLP-1 receptor agonist.
• Mounjaro contains tirzepatide, which works on both GLP-1 and GIP receptors. This “dual action” is thought to give Mounjaro an edge in effectiveness for many patients.

Effectiveness

• Mounjaro studies have shown slightly greater average weight loss compared to Wegovy. Some patients lose more significant amounts of weight with Mounjaro, though results vary individually.

Side Effects

• Both can cause nausea, bloating, constipation, or diarrhoea - especially at the start.
  

Costings

• Wegovy is often slightly less expensive than Mounjaro, but not by a large margin.
• Mounjaro prices have recently increased substantially to match the costs of the drug across Europe and other parts of the world.

Which One Should You Choose?

There’s no one-size-fits-all answer. For some, Wegovy is a good option, especially if cost is the main factor. For others, Mounjaro’s dual-action mechanism may deliver better results, making it worth the extra investment.

The best choice depends on your medical history, personal goals, tolerance of side effects, and budget. That’s why it’s always important to discuss options with a healthcare professional before making a decision.

✅ Bottom line: Both Wegovy and Mounjaro can be highly effective tools for weight management. Mounjaro may have a slight edge in results, but Wegovy remains a strong alternative. The right option is the one that works best for you after careful discussion with your prescriber.